Drug Standards
Apexbio Technology LLC Gabapentin HCl 60142-95-2 10mM (in 1mL H2O)
Gabapentin HCl (CAS 60142-95-2) is a structurally related analog of gamma-aminobutyric acid (GABA) though it does not bind directly to GABA receptors Its primary mechanism involves binding to the 2 subunit of voltage-gated calcium channels in neuronal tissues resulting in decreased neurotransmitter release Originally investigated for antiepileptic properties gabapentin has been widely utilized in research exploring neuropathic pain modulation and neuronal excitability This molecule serves as a tool compound for studying calcium channel modulation and the pathophysiology of neurological disorders
Apexbio Technology LLC Haloperidol 52-86-8 1g
Haloperidol is a small-molecule antagonist targeting dopamine receptors It is designed to block dopamine signaling thereby modulating neurotransmission within cortical limbic and nigrostriatal pathways Haloperidol exerts its biological activity primarily through inverse agonism at dopamine receptors Based on these pharmacological properties Haloperidol holds research potential in psychiatric and neuropsychological applications including studies of delirium delusions hallucinations and characterization of dopamine-mediated neuronal circuits and behavioral models in psychiatric disorders
Apexbio Technology LLC Nitisinone 104206-65-7 10mg
Nitisinone (CAS 104206-65-7) is a synthetic small molecule that selectively inhibits 4-hydroxyphenylpyruvate dioxygenase an enzyme involved in the catabolic pathway of tyrosine By blocking this enzyme nitisinone disrupts the conversion of 4-hydroxyphenylpyruvate to homogentisic acid leading to reduced production of toxic tyrosine metabolites This mechanism is utilized in studies of hereditary tyrosinemia type 1 where nitisinone serves as a pharmacological tool to investigate metabolic regulation and therapeutic intervention in tyrosine degradation disorders
Selleck Chemical LLC Dexamethasone Acetate 50mg 1177-87-3 NSC 39471
Dexamethasone (NSC 39471) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Dexamethasone Acetate 10mM/1mL 1177-87-3 NSC 39471
Dexamethasone (NSC 39471) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Ticagrelor impurity 11 | 220352-36-3 | ≥95.0% | C10H8F2O2 | 500 MG
Ticagrelor impurity 11 is an impurity of Ticagrelor, presented as a solid powder. This chemical is intended for laboratory research use and the manufacture of substances.
- Impurity of Ticagrelor
- Presented as a solid powder
- For laboratory research use only
- Purity greater than or equal to 95.0%
- Stable as powder at -20°C for 3 years or 4°C for 2 years
- Stable in solvent at -80°C for 6 months or -20°C for 1 month
Apexbio Technology LLC Fluconazole hydrate 155347-36-7 1g
Fluconazole hydrate (CAS 155347-36-7) is a small-molecule inhibitor targeting the fungal enzyme lanosterol 14 -demethylase It is designed to inhibit ergosterol biosynthesis thereby disrupting fungal cell membrane integrity and arresting fungal growth Fluconazole hydrate exerts its biological activity primarily through inhibition of lanosterol 14 -demethylase In in vitro studies fluconazole hydrate demonstrates inhibitory activity with documented IC50 values typically ranging from 0 1 to 10 g/mL depending on fungal strain and experimental conditions Based on these pharmacological properties fluconazole hydrate holds research potential in antifungal pharmacology assays fungal infection model studies and evaluation of combinational antifungal therapies
Medchemexpress LLC Magnolol | 528-43-8 | 99.8% | 266.33 | 100 MG
Magnolol is a natural lignan isolated from the stem bark of Magnolia officinalis. It acts as a dual agonist for both RXRα and PPARγ. It binds to RXRαLBD and PPARγLBD, inducing transcription of PPRE.
- Natural lignan isolated from Magnolia officinalis.
- Dual agonist of RXRα and PPARγ.
- Binds to RXRαLBD and PPARγLBD in a dose-dependent manner.
- Induces transcription of PPRE in a dose-dependent manner.
- Enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells.
- Attenuates dextran sulfate sodium (DSS)-induced colitis in mice.
- Decreases DSS-induced proinflammatory cytokines (TNF-α, IL-1β, IL-6).
- Regulates tryptophan metabolic pathway in mice.
Selleck Chemical LLC Motolimod (VTX-2337) 5mg 926927-61-9
Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Batimastat (BB-94) 10mg 130370-60-4
Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC (S)-Flurbiprofen 51543-39-6 500mg
(S)-Flurbiprofen (CAS 51543-39-6) is the pharmacologically active enantiomer of the 2-aryl propionic acid class of non-steroidal anti-inflammatory drugs (NSAIDs) It acts as a dual inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with an IC50 of approximately 0 5 M against both isoforms in guinea pig whole blood assays In preclinical models topical administration of (S)-Flurbiprofen demonstrated significant analgesic and anti-inflammatory effects reducing inflammatory pain and edema in rat arthritis experiments Clinical studies have also supported its analgesic efficacy and safety in the management of osteoarthritis This compound is widely used in research focused on inflammation pain modulation and cyclooxygenase inhibition
Medchemexpress LLC 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole | 1231930-33-8 | 99.4% | C11H12BrFN2 | 500MG
Abemaciclib Impurity 1 is a drug intermediate designed for the synthesis of various active compounds. It is supplied as an off-white to yellow solid with a purity of 99.4%.
- A drug intermediate for chemical synthesis
- Appearance as an off-white to yellow solid
- Purity of 99.4%
- Powder storage at -20°C for 3 years or 4°C for 2 years
- In-solvent storage at -80°C for 6 months or -20°C for 1 month
Apexbio Technology LLC Capreomycin Sulfate 1405-37-4 5g
Capreomycin sulfate (CAS 1405-37-4) is a cyclic peptide antibiotic targeting the bacterial 70S ribosomal subunit It is designed to disrupt translation processes thereby inhibiting bacterial protein biosynthesis Capreomycin sulfate exerts its biological activity primarily through specific binding to the ribosomal subunit inhibiting protein synthesis In in vitro studies Capreomycin sulfate demonstrates inhibitory activity with reported IC50 values typically ranging from approximately 2 to 10 g/mL dependent upon the bacterial species and experimental conditions Based on these pharmacological properties Capreomycin sulfate holds research potential in antimicrobial susceptibility testing and the study of resistance mechanisms in Mycobacterium tuberculosis strains